Curriculum Vitae

Updated January 2011

Norman A. Marcus, M.D.
Orthopaedic Surgery and Cartilage Restoration
8346 Traford Lane
Springfield, Virginia 22152
(703) 569-6700

EDUCATION
Newton High School, Newtonville, Massachusetts, 1967-1970
Johns Hopkins University, Baltimore, Maryland, 1970-1974, B.A. degree
Stanford University School of Medicine, 1974-1978, M.D. degree
Internship and Residency: University of New Mexico Affiliated
Hospitals, Albuquerque, New Mexico,
Department of Orthopaedic Surgery and Rehabilitation, 1978-1983

HONOR SOCIETIES
Phi Beta Kappa
Alpha Epsilon Delta

PROFESSIONAL ORGANIZATIONS
Diplomate, American Board of Orthopaedic Surgeons, 1985
Fellow, American Academy of Orthopaedic Surgery 1987
Member, International Cartilage Research Society
Member, Orthopaedic Research Society
Member, International Society for Stem Cell Research

STAFF PRIVILEGES and APPOINTMENTS
Courtesy, INOVA Fairfax Hospital, Falls Church, Virginia
INOVA Springfield Franconia Surgical Center, Alexandria, Virginia
Northern Virginia Surgery Center, Fair Oaks, VA
Reston Surgery Center, Reston VA
Adjunct Professor, Johns Hopkins University

RESEARCH AND CLINICAL INVESTIGATIONS
September 1970-December 1972: Perceptual Psychology research under the direction of Dr. Howard Egeth, Department of Psychology, Johns Hopkins University School of Medicine.

January 1973-July 1974: Membrane chemistry and hormone biochemistry research under the direction of Dr. Pedro Cuatrecasas, Johns Hopkins University School of Medicine.

July 1976-January 1983: Hand surgery, Children’s Orthopaedic and Trauma under the direction of Dr. George Omer, University of New Mexico Medical Center, Albuquerque, New Mexico.

Project: Principal Investigator, Darbepoetin Study, Sponsor: AMGEN “A Double Blind, Randomized, Placebo Controlled Study to Evaluate the Efficacy and Safety of Single-dose, subcutaneous (SC) Darbepoetin Alfa in Subject Undergoing Preoperative Autologous Blood Donation (PAD) before Elective Revision Total Hip Replacement or Bilateral Total Knee Surgery.”

Project: Principal Investigator, Darbepoetin Study. Sponsor AMGEN “ An open label study to compare autologous blood donation with darbepoetin for total joint replacement”.

Principal Investigator, Zolendronate Study, Sponsor: NOVARTIS “ A multinational, multicenter, double blind, randomized, placebo controlled parallel group study assessing the efficacy of zoledronic acid in preventing subsequent osteoporotic fractures after a hip fracture” 2001-2002

Principal Investigator and Study Director: Genomic Analysis of Hyalgan Responders; Investigational grant from Sanofi-Synthelabo. 2003-2005

Collaboration, Dept. of Genomics, George Mason University 2001-2004

Collaboration, Dept. of Chemistry (Hunt Lab), University of Virginia 2001-2005

Tissue Engineering of Cartilage (ongoing collaboration) with Jennifer Elisseef Ph.D., Dept. of Biomedical Engineering, Johns Hopkins University, Baltimore, MD.

OCCUPATION AND BUSINESS HISTORY
1. Orthopaedic Surgery, Private Practice, Springfield, Virginia, 1983-present
2. Founding Member, Chairman of the Board and Chief Executive Officer, Medtrust Medical Group, 1996-1998
3. Founder, Chief Science Officer, Cell Mechanics LLC, 2001-2003
4. Co-Founder and Chief Medical Officer, Cartilix, Inc., 353 Vintage Park Dr., Foster City, CA, 2004- present. Product development of new medical device(s); fundraising and business development; Member, Board of Directors; designer and surgical instructor for European Study (in 5 countries) for a novel cartilage repair device (2006-2009).
5. Sold Cartilix Inc. to Biomet Inc., October 2009
6. Consultant to Cytomedix, Inc, a biotech company in Rockville, MD
7. Consultant to Zimmer, Inc

PRESENTATIONS
1. Total Knee Arthroplasty: The Lovelace Clinic Experience, presented to the New Mexico Medical Society, September 1980.

2. Hot-Air Ballooning Injuries, presented to the American Orthopaedic Society for Sports Medicine Annual Meeting, Big Sky, Montana, July 1980; and to the New Mexico Medical Society, September 1981.

3. Congenital Ulnar Dysmelia, presented to the Carrie Tingle Hospital summer seminar on Pediatric Orthopaedics, Albuquerque, New Mexico, June 1981; and to the AOA Residents Conference, Washington D.C., April 1982.

4. Upper Extremity Amputation in Children, presented to the Carrie Tingle Hospital winter Seminar on Pediatric Orthopaedics, Albuquerque, New Mexico, January 1982.

5. Cephalosporin Use in Orthopaedic Surgery, presented to the University of New Mexico Annual Alumni Seminar in Adult Orthopaedics, Albuquerque, New Mexico, July 1982.

6. Upper Extremity Amputation in Children, presented to the Residents and Fellow Hand Surgery Conference, American Society for Surgery of the Hand, Anaheim, California, March 1983.

7. Congenital Ulnar Deficiency, presented to the American Academy of Orthopaedic Surgeons Annual Meeting, Anaheim, California, March 1983.

8. Muscle Rehabilitation, presented to the 2nd Annual Kin-Com Conference, Tampa, Florida, January
1986.

9. Care of the Injured Athlete, presented to Primary Care Problems Course, Cancun, Mexico, February 1991.

10. Future Innovations in Orthopaedics & Current Research for “Orthopaedic Nursing”, Professional & Practice Issues Course, October 1992.

11. Orthopaedic Nursing Symposium presented at the McLean Hilton, October 1992.

12. Management of the ACL Deficient Knee, presented at the Kin-Com meeting, Orlando, Florida, October 1992.

13. Cartilage Genomics, presented by invitation at AMGEN Corporation, Thousand Oaks California, May 2002.

14. Differential Gene Expression in Normal and Osteoarthritic Human Chondrocytes Grant Geraldine, Marcus N, et. al International Cartilage Society, Toronto, Canada, June 16 2002

15. Microarray Analysis of Human Chondrocytes Marcus, N., Grant, G. Christensen, A. et. al accepted for March 2003, ISAKOS Conference, Auckland, New Zealand

16. The prevention of Deep Venous Thrombosis, presented at the Willard Hotel, August 28, 2002, conference on Strategies in DVT Prevention.

17. The Future of Cartilage Biotechnology, presented at INOVA Fairfax Hospital as part of of the Cartilage Symposium, October 2002.

18. Mass Spectrometric Analysis of Chondrocyte Proteomics, accepted for the OARSI international arthritis meeting, 10/12/03, Berlin Germany.

19. Cartilage Tissue Engineering, presented as Medical grand Rounds, INOVA Fairfax Hospital, Falls Church, Virginia, April 2004

20. Stem Cells and Tissue Engineering,  presented at Grand Rounds, INOVA Mt. Vernon Hospital, Alexandria Virginia October 2004.

21. Biomaterial Guided Cartilage Repair in a Goat Model, Presented at the Cleveland Cartilage Innovation Summit, May 9. 2008, Cleveland Ohio. (Poster session). Sharma B., Fermanian, S, Cascio, B, Marcus N, & Elisseeff J.

22. A Prospective Clinical Study Evaluating Biomaterial Guided Cartilage Repair in the Knee, Accepted to the Orthopaedic Research Society, Feb 22, 2009 Las Vegas Nevada USA.