So far the first 11 patients with “amniotic” injections are doing fine, no complications and 10/11 experiencing little if any symptoms; in other words, PRP plus the amniotic fluid appears to be as good as PRP alone. It is still too early to determine if the addition of the amniotic fluid is better than PRP alone. Since this is not a controlled, blinded study, we will have to use prior knowledge and expectations to make a judgement of this kind.
As to the fluid, it contains a variable number of cells that appear in the cell counter as either lymphocytes or granulocytes. As expected, quality control of cell number is problematic and is not being done at the tissue bank on each lot. We are in the process of analyzing the growth factors in the fluid, which of course may be equally or more important than the cells. Stay tuned.
Dr. Marcus to teach E & E at George Mason University this Spring Semester 2016.
On Fri Nov 13 Dr. Marcus spoke to the entrepreneurs at Johns Hopkins Medical School about concepts in funding new ventures. The Group is Called Hexcite!
We now have access to a source of stem cells derived from healthy deliveries (C sections) and screened thoroughly by an accredited tissue bank. These are allograft cells, meaning, from a different person, and do not require tissue matching because they do not possess immunogenic surface antigens. The cells arrive frozen in dry ice, and must be used on the day of arrival. The present plan is to combine the cells with the growth factors of PRP. The cost of these cells is moderate, especially compared with charges for bone marrow aspirate that are offered in other centers.
Please inquire if this exciting new addition to our technology is of interest to you.
Dr. Marcus will be in Stuart Florida to talk about Surface and Sub-surface reconstruction of the damaged joint.
April 5, Waterview Conference Center
Topic: Juvenile Allograft for Cartilage Reconstruction
Dr. Marcus is to speak on the role of PRP and Cartilage Repair at the forthcoming Sanibel Perfusion Symposium, Ft. Myers Fla.
Feb 15, 2014.
Dr. Marcus was elected as a Senior Fellow and Honorary member of the ICRS (International Cartilage Repair Society) in recognition of his contributions
to the field and for being a thought leader in cartilage repair.
May 2, Tyler Texas
May 16, Shreveport, Louisiana
May 23 Las Vegas Nevada
June 13, Des Moines, Iowa
June 20, Minneapolis, Minnesota
Developments by Dr. Eric Giza (Sacramento, CA) and Dr. Andrew Wolff (Arlington, VA) are pushing the technology of Denovo NT insertion into the realm of arthroscopy. It is possible to insert the particles of Denovo NT through a tube (cannula)and to glue them in position in either the hip or the ankle joint. Now with over 6000 implants in patients, these improvements will no doubt further the use of this implant.