Platelet Rich Plasma (PRP) and gene expression

Please see previous notes on this web site regarding PRP.

In the August edition of the Journal of Sports Medicine( ) we now have gene expression evidence of PRP effects for patients with osteoarthritis.

What this may mean is that the potential activity of PRP is, in fact, real.  PRP is  a medley of bioactive proteins, including growth factors that may control protein manufacture. In regenerative medicine, it is precisely the manufacture of proteins that we are seeking to influence.  We know that activated platelet contain over 1000 such proteins;how they may promote healing and regeneration is still very much an issue.

So this study referenced above seeks to measure a precise effect upon DNA.  The effect measured shows a reduction in the inflammatory protein IL-1, a known component of joint inflammation, hence a desirable treatment of osteoarthritis. For those of us who have been treating osteoarthritis with PRP, this is a welcome finding. In part, it explains the favorable clinical result we have been observing.

There is much work to be done. Clearly some genes will be up-regulated and some down-regulated, and it is the balance between the two that needs to be assessed.